The No. 2 Penn State Nittany Lions (2-0) face an FCS opponent, the Villanova Wildcats (1-0), on Saturday, September 13, 2025 at West Shore Home Field at Beaver Stadium.

The Nittany Lions are expected to win by at least two touchdowns (currently -47.5) versus the Wildcats. The over/under for this matchup is 56.5 points.

Read on for our preview for this this contest between the Nittany Lions and the Wildcats, and find all of our betting picks here, too!

Penn State vs. Villanova betting lines

• Spread favorite: Nittany Lions (-47.5)
• Moneyline: Nittany Lions (), Wildcats ()
• Total: 56.5 points
• TV Channel: FOX Sports 1
• Live Stream: Fubo

Penn State vs. Villanova betting info and stats

Penn State has not won a game against the spread so far this season (0-2-0). In one game as the moneyline favorite, Penn State won. Villanova, through one game with a set spread this season, has gone 0-1-0 against the spread. Villanova has not played a game as an underdog on the moneyline so far this season.

Penn State vs. Villanova key players

Penn State Nittany Lions

• Drew Allar had a passing stat line last season of 3,327 yards with a 66.5% completion rate (262-for-394), 24 touchdowns, eight interceptions, and an average of 207.9 yards per game. His rushing stat line was 96 carries for 302 yards and six TDs.
• Last season, Kaytron Allen ran for 1,108 yards on 220 carries (69.3 yards per game) and scored eight times.
• Nicholas Singleton ran for 1,099 yards on 172 carries (68.7 yards per game), with 12 rushing touchdowns last year. He also made his name known on the passing side with 41 receptions for 375 yards (25.0 per game) and five TDs.
• In the previous season, Tyler William Warren grabbed 104 passes (on 138 targets) for 1,233 yards (77.1 per game). He also found the end zone eight times.
• Harrison Wallace III also impressed receiving last year. He bagged 46 receptions for 720 yards and four touchdowns. He was targeted 79 times.
• Omari Evans’ stat line last year: 415 receiving yards, 21 catches, five touchdowns, on 38 targets.
• Abdul Carter did his thing last season with an incredible stat line of 12.0 sacks, 18.0 TFL and 55 tackles.
• Zakee Wheatley was a wrecking ball on the field, collecting 74 tackles, 2.0 TFL, one sack, and three interceptions last year.
• Last season Tony Rojas had a huge stat line of three interceptions, 49 tackles, 5.0 TFL, 1.5 sacks, and three passes defended.

Villanova Wildcats

• Connor Watkins threw for 2,102 yards and 13 touchdowns last season. He also chipped in on the ground, tallying eight touchdowns while racking up 430 yards.
• David Avit averaged 65.9 rushing yards and tallied nine rushing touchdowns. Avit complemented his performance on the ground with 0.8 receptions per game to average 15.9 receiving yards.
• Last season Isaiah Ragland rushed for 511 yards. He also scored four total touchdowns.
• Jaylan Sanchez averaged 38.4 receiving yards and collected three receiving touchdowns over the course of the 2024 season.
• Devin Smith hauled in six touchdowns and had 483 receiving yards (37.2 ypg) in 2024.
• Lucas Kopecky averaged 21.6 receiving yards per game on 2.4 targets per game a season ago.
• Last year Nigel McSween racked up 4.5 sacks, 1.0 TFL.
• Brendan Bell had an impactful defensive performance last season with 18 tackles, 1.0 TFL, three sacks, and one interception.
• Last year Ty Trinh picked off three passes to go along with 14 tackles, 3.0 TFL, and one pass defended.