The Pittsburgh Panthers (5-2) take on a fellow ACC opponent when they host the NC State Wolfpack (4-3) on Saturday, October 25, 2025 at Acrisure Stadium.

The Panthers are the favorites (-6.5) in their matchup against the Wolfpack, with the over/under at 54.5 points. (On the moneyline, the Panthers are -239 and the Wolfpack are +193.)

Keep reading for our betting preview for this this matchup between the Panthers and the Wolfpack, and find all of our expert predictions here, too!

Pittsburgh vs. NC State betting lines

• Spread favorite: Panthers (-6.5)
• Moneyline: Panthers (-239), Wolfpack (+193)
• Total: 54.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Pittsburgh vs. NC State betting info and stats

Pittsburgh has a 5-2-0 record against the spread so far this season. Pittsburgh has covered the spread four times when listed as a favorite by 6.5 or more points this season (4-1 ATS). Pittsburgh has been moneyline favorites in five games this season, and it has put up a 4-1 record in those contests. NC State has won three games against the spread this season (3-4-0). When NC State is an underdog of 6.5 points or more, it has have yet to cover the spread. This is the third game this year NC State is the moneyline underdog, after losing the previous two such games.

Pittsburgh vs. NC State recent stats and trends

Pittsburgh Panthers

• Pittsburgh has covered the spread in its last three contests while putting up a 3-0 record straight-up in those games.
• Pittsburgh and its opponents have hit the over once in those games.
• The last three Pittsburgh games averaged 55.7 total points, 1.2 more points than this matchup’s over/under.

NC State Wolfpack

• NC State is 1-2 against the spread and 3-0 overall over its past three contests.
• The final combined score of the last three NC State games surpassed the set total once.
• NC State’s last three outings have ended with an average of 59.5 points scored. That’s 5.0 more points than this contest’s over/under.

Pittsburgh vs. NC State key players

Pittsburgh Panthers

• Eli Holstein has thrown for 1,058 yards (211.6 ypg) to lead Pittsburgh, completing 62.7% of his passes and tossing 11 touchdown passes compared to five interceptions this season. He’s also contributed in the ground game with 83 rushing yards on 34 carries with one rushing touchdown.
• The team’s top rusher, Desmond Reid, has carried the ball 42 times for 225 yards (45.0 per game) and one touchdown. He’s proven to be a dual threat, racking up 226 receiving yards on 14 catches with two touchdowns through the air.
• Ja’Kyrian Turner has been handed the ball 53 times this year and racked up 224 yards (37.3 per game) with four touchdowns.
• Raphael Williams’ leads his squad with 466 yards as a receiver. He’s racked up that yardage on 28 receptions (out of 43 targets) and scored four touchdowns.
• Kenny Johnson has grabbed 25 passes while averaging 50.4 yards per game and scoring two touchdowns.
• Blaine Spires paces the team with 2.5 sacks, and also has 4.0 TFL and 12 tackles.
• Rasheem Biles is the team’s tackle leader this year. He’s amassed 51 tackles, 5.0 TFL, two sacks, and one interception.
• Shadarian Harrison leads the team with one interception, while also putting up 20 tackles and one pass defended.

NC State Wolfpack

• CJ Bailey leads NC State with 1,846 yards on 155-of-215 passing with 14 touchdowns compared to seven interceptions this season.
• The team’s top rusher, Daylan Smothers, has carried the ball 112 times for 739 yards (105.6 per game) with five touchdowns. He’s also caught 25 passes for 145 yards and one touchdown.
• Jayden Scott has run for 211 yards across 44 attempts, scoring three touchdowns.
• Terrell Anderson has racked up 445 receiving yards on 24 catches to pace his squad so far this season while scoring four touchdowns as a receiver.
• Justin Joly has put up a 264-yard season so far with three touchdowns. He’s caught 30 passes on 43 targets.
• Wesley Grimes’ 14 grabs (on 24 targets) have netted him 243 yards (40.5 ypg) and one touchdown.
• Travali Price has collected 2.5 sacks to pace the team, while also recording 3.0 TFL and 14 tackles.
• Caden Fordham, NC State’s top tackler, has 67 tackles, 3.0 TFL, and two sacks this year.
• Isaiah Shirley leads the team with one interception, while also putting up 12 tackles and one pass defended.