The Pittsburgh Panthers (4-2) square off against a conference opponent when they visit the Syracuse Orange (3-3) on Saturday, October 18, 2025 at the JMA Wireless Dome in an ACC battle.
The Panthers are significant favorites (-9.5) in their matchup versus the Orange, with the over/under being 54.5 points. (On the moneyline, the Panthers are -364 and the Orange are +289.)
Read on for our preview for this this contest between the Panthers and the Orange, and uncover all of our betting picks here, too!
To Cover the Spread
Bet $20, Payout $38.02
Pittsburgh -9.5 vs. Syracuse
Pittsburgh vs. Syracuse betting lines
- Spread favorite: Panthers (-9.5)
- Moneyline: Panthers (-364), Orange (+289)
- Total: 54.5 points
- TV Channel: ACC Network
- Live Stream: Fubo
Pittsburgh vs. Syracuse betting info and stats
- Pittsburgh has an against-the-spread record of 4-2-0 so far this season. Pittsburgh has always covered the spread when the favorite by at least 9.5 points (a 2-0 ATS record). Pittsburgh has put together a 3-1 record in the four games this season it has been the moneyline favorite. Syracuse has a 3-2-1 record against the spread so far this season. In the three games Syracuse has been the underdog by at least 9.5 points, it covered the spread two times. Syracuse’s record in games it’ve played as an underdog this year is 1-3.
Pittsburgh vs. Syracuse recent stats and trends
Pittsburgh Panthers
- Pittsburgh is 2-1 against the spread over its past three games, and has a 2-1 straight-up record in those contests.
- Pittsburgh and its opponents have combined to hit the over in two of those games.
- The last three Pittsburgh games averaged 56.0 total points, 1.5 more points than this matchup’s over/under.
Syracuse Orange
- Syracuse has covered the spread twice in its past three matchups while putting up a 2-1 record straight-up in those games.
- The final combined score of the last three Syracuse games surpassed the set total once.
- Syracuse’s last three outings have ended with an average of 57.2 points scored. That’s 2.7 more points than this contest’s over/under.
Pittsburgh vs. Syracuse key players
Pittsburgh Panthers
- Eli Holstein has thrown for 1,058 yards (211.6 ypg) to lead Pittsburgh, completing 62.7% of his passes and collecting 11 touchdown passes compared to five interceptions this season. He’s also figured in the ground game with 83 rushing yards on 34 carries with one rushing touchdown.
- Desmond Reid has carried the ball 36 times for a team-high 187 yards (46.8 per game) with one score. He has also caught 14 passes for 226 yards and two receiving touchdowns.
- Ja’Kyrian Turner has carried the ball 38 times for 182 yards (36.4 per game) and four touchdowns.
- Raphael Williams’ leads his squad with 438 yards as a receiver. He’s racked up that yardage on 25 catches (out of 38 targets) and scored four touchdowns.
- Kenny Johnson has caught 21 passes while averaging 49.0 yards per game and scoring two touchdowns.
- Blaine Spires leads the team with 2.5 sacks, and also has 4.0 TFL and 12 tackles.
- Rasheem Biles, Pittsburgh’s leading tackler, has 51 tackles, 5.0 TFL, two sacks, and one interception this year.
- Shadarian Harrison has a team-high one interception to go along with 20 tackles and one pass defended.
Syracuse Orange
- Steve Angeli has thrown for 1,352 yards (338.0 ypg) while completing 62.8% of his passes and recording 10 touchdown passes with two interceptions this season.
- Yasin Willis has carried the ball 78 times for 337 yards, with four touchdowns.
- Will Nixon has piled up 54 carries and totaled 210 yards with two touchdowns while also gaining 124 yards through the air .
- Johntay Cook II has hauled in 390 receiving yards on 31 catches to pace his squad so far this season while scoring two touchdowns as a receiver.
- Darrell Gill Jr. has collected 342 receiving yards (57.0 yards per game) and three touchdowns on 17 receptions.
- Dan Villari’s 27 receptions (on 36 targets) have netted him 311 yards (51.8 ypg).
- Braheem Long Jr. leads the team with 2.0 sacks, and also has 2.0 TFL, 26 tackles, and one interception.
- Gary Bryant III is the team’s top-tackler this year. He’s totaled 33 tackles and 1.0 TFL.
- Davien Kerr leads the team with two interceptions, while also collecting 10 tackles and two passes defended.
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