The South Carolina Gamecocks (4-7) and the Clemson Tigers (6-5) play at Williams-Brice Stadium on Saturday, November 29, 2025.
The Gamecocks are small favorites (-2.5) in their matchup versus the Tigers, with the over/under being 46.5 points. (On the moneyline, the Gamecocks are -138 and the Tigers are +116.)
Keep reading for our betting preview for this this matchup between the Gamecocks and the Tigers, and find all of our expert picks here, too!
Spread
Bet $20, Payout $37.70
South Carolina -2.5 vs. Clemson
South Carolina vs. Clemson betting lines
- Spread favorite: Gamecocks (-2.5)
- Moneyline: Gamecocks (-138), Tigers (+116)
- Total: 46.5 points
- TV Channel: SEC Network
- Live Stream: Fubo
South Carolina vs. Clemson betting info and stats
- South Carolina, in 11 games with a spread so far this season, is 6-5-0 against the spread. South Carolina has covered the spread in three of the games this season when a favorite of at least 2.5 points (3-2 ATS). South Carolina is 3-1 in the four games this season it has been moneyline favorites. Clemson has an against-the-spread record of 4-7-0 so far this season. When Clemson is an underdog by 2.5 points or more, it has posted a record of 1-0 ATS. Clemson has been the underdog on the moneyline once this season, and won that game.
South Carolina vs. Clemson recent stats and trends
South Carolina Gamecocks
- South Carolina has covered the spread twice in its past three contests while putting up a 1-2 record straight-up in those games.
- South Carolina and its opponents have hit the over twice in those games.
- The last three South Carolina games averaged 51.8 total points, 5.3 more points than this matchup’s point total.
Clemson Tigers
- Clemson is 2-1 against the spread and 1-2 overall during its past three contests.
- Clemson and its opponents did not combine to hit the over in any of those games.
- The last three Clemson games averaged 54.5 total points, 8.0 more points than this matchup’s point total.
South Carolina vs. Clemson key players
South Carolina Gamecocks
- LaNorris Sellers has been a dual threat for South Carolina so far this season. He has 2,056 passing yards, completing 61.8% of his passes and recording 11 touchdown passes and six interceptions this season. He’s rushed for 268 yards (24.4 ypg) on 137 carries with five rushing touchdowns.
- Rahsul Faison has 433 rushing yards on 91 carries with three touchdowns.
- Nyck Harbor’s team-leading 503 yards as a receiver have come on 24 catches (out of 41 targets) with five touchdowns.
- Vandrevius Jacobs has hauled in 25 passes while averaging 45.2 yards per game and scoring three touchdowns.
- Jayden Sellers has racked up 17 catches for 270 yards, an average of 54.0 yards per game. He’s scored one time as a receiver this season.
- Bryan Thomas Jr. has 7.0 sacks to pace the team, and also has 7.0 TFL and 33 tackles.
- Justin Okoronkwo is the team’s leading tackler this year. He’s amassed 59 tackles, 4.0 TFL, and one interception.
- Vicari Swain leads the team with two interceptions, while also recording 24 tackles, one sack, and two passes defended.
Clemson Tigers
- Cade Klubnik has racked up 2,482 yards (248.2 per game) while completing 67.2% of his passes and tossing 16 touchdown passes with five interceptions this season.
- Adam Randall has rushed for 677 yards on 133 carries so far this year while scoring eight times on the ground. He’s also tacked on 30 catches, totaling 247 yards and three touchdowns in the passing game.
- Gideon Davidson has run for 225 yards across 48 attempts. He’s chipped in with 10 catches for 80 yards.
- T.J. Moore has hauled in 653 receiving yards on 40 catches to pace his team so far this season while scoring four touchdowns as a receiver.
- Antonio Williams has totaled 538 receiving yards (59.8 yards per game) and four touchdowns on 48 receptions.
- Bryant Wesco Jr.’s 45 targets have resulted in 31 grabs for 537 yards and six touchdowns.
- Will Heldt has 5.0 sacks to lead the team, and also has 9.0 TFL and 35 tackles.
- Clemson’s top-tackler, Sammy Brown, has 75 tackles, 9.0 TFL, five sacks, and one interception this year.
- Ricardo Jones has picked off a team-high four passes. He also has 33 tackles, 1.0 TFL, and four passes defended to his name.
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