Cardinals vs. Diamondbacks Betting Lines, Odds, & Player Matchups June 22, 2026

Data Skrive

The St. Louis Cardinals (41-34) play the Arizona Diamondbacks (39-38) a game after JJ Wetherholt homered twice in a 12-10 win over the Royals. The Cardinals are favored (-144) in this matchup with the Diamondbacks (+118), which starts at 7:45 p.m. ET on Monday. St. Louis’ Andre Pallante and Arizona’s Merrill Kelly will start this matchup.

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Betting Odds

Cardinals to win vs Diamondbacks -144

Bet $20, Payout $33.89

Cardinals vs. Diamondbacks betting lines

  • Favorite: Cardinals (-144)
  • Underdog: Diamondbacks (+118)
  • Over/under: 8.5

Cardinals betting info, hitting leaders, & pitching

Cardinals betting info

  • The Cardinals have been the moneyline favorite 19 total times this season. They’ve gone 13-6 in those games.
  • St. Louis has played as moneyline favorites of -144 or shorter in just two games this season, which it won both.
  • The Cardinals have an implied moneyline win probability of 59% in this matchup.
  • St. Louis has had an over/under set by oddsmakers 75 times, and have combined with opponents to go over the total in 31 of those games (31-37-7).
  • The Cardinals have gone 46-29-0 ATS this season.

Cardinals hitting info

  • Alec Burleson is hitting .287 with 19 doubles, a triple, 13 home runs and 28 walks.
  • In MLB, Burleson ranks 40th in homers and sixth in RBI.
  • Burleson takes a two-game hitting streak into this matchup. During his last five outings he is hitting .286 with a double, a triple, two walks and three RBIs.
  • Jordan Walker has hit 18 home runs with 58 runs batted in while hitting .291. Those stats are all team-highs.
  • Walker ranks 12th in home runs and second in RBI this season.
  • Ivan Herrera is hitting .265 with 13 doubles, a triple, 10 home runs and 45 walks.
  • Herrera brings a two-game hitting streak into this game. In his last five games he is batting .294 with a home run, three walks and four RBIs.
  • Wetherholt has eight doubles, 12 home runs and 35 walks while hitting .268.

Cardinals pitching rankings

  • The pitching staff for the Cardinals has a collective 7.7 K/9, the fourth-worst in the majors.
  • St. Louis’ 4.30 team ERA ranks 18th across all MLB pitching staffs.
  • The Cardinals have the 20th-ranked WHIP in MLB (1.347).
  • The Cardinals give up the 15th-fewest home runs in baseball (86 total, 1.1 per game).
  • St. Louis struck out nine Royals batters while allowing 12 hits in a 12-10 win in its last game.

Diamondbacks betting info, hitting leaders, & pitching

Diamondbacks betting info

  • The Diamondbacks have won 16, or 40%, of the 40 games they’ve played as underdogs this season.
  • Arizona is 5-11 this season when entering a game as the underdog by +118 or more on the moneyline.
  • Sportsbooks have implied with the moneyline set for this matchup that the Diamondbacks have a 45.9% chance to win.
  • Games involving Arizona have gone over the total set by oddsmakers in 34 of 77 chances this season.
  • The Diamondbacks are 43-34-0 against the spread in their 77 chances this season.

Diamondbacks hitting info

  • Corbin Carroll is batting .281 this season with 13 home runs, both rank first among Arizona hitters.
  • Carroll is 40th in home runs and 36th in RBI among all hitters in the majors.
  • Ketel Marte leads Arizona in runs batted in (46) this season. He’s batting .259 while slugging .451.
  • Among all MLB hitters, Marte ranks 49th in homers and 23rd in RBI.
  • Geraldo Perdomo has 61 hits this season and a slash line of .241/.358/.352.
  • Ildemaro Vargas has collected 62 hits this season and has an OBP of .301. He’s slugging .404 on the year.

Diamondbacks pitching rankings

  • The Diamondbacks have a 7.1 K/9 this season as a pitching staff, worst in baseball.
  • Arizona has the 19th-ranked ERA (4.31) in the majors this season.
  • Diamondbacks pitchers have a 1.300 WHIP this season, 15th in the majors.
  • The Diamondbacks have given up the 23rd-fewest long balls so far this season with 93 home runs allowed.
  • Arizona pitchers struck out three Twins hitters while allowing 20 base hits in a 16-8 loss its last time out.
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