Cardinals vs. Pirates Betting Lines, Odds, & Player Matchups May 20, 2026

Data Skrive

The Pittsburgh Pirates (24-24) will attempt to stop a four-game losing streak when they visit the St. Louis Cardinals (28-19) on Wednesday at 7:45 p.m. ET. The Pirates (+100) are not projected to end the streak against the Cardinals (-120). St. Louis’ Michael McGreevy and Pittsburgh’s Carmen Mlodzinski pitch first for their squads in this matchup.

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Money Line

Cardinals to win vs Pirates -120

Bet $20, Payout $36.67

Cardinals vs. Pirates betting lines

  • Favorite: Cardinals (-120)
  • Underdog: Pirates (+100)
  • Over/under: 7.5

Cardinals betting info, hitting leaders, & pitching

Cardinals betting info

  • The Cardinals have gone 4-3 in games they were favored on the moneyline (winning 57.1% of those games).
  • St. Louis has played as moneyline favorites of -120 or shorter in just two games this season, which it split 1-1.
  • Based on this contest’s moneyline, the Cardinals have an implied win probability of 54.5%.
  • St. Louis has played in 47 games with an over/under set, and have combined with its opponents to go over the total 19 times (19-23-5).
  • The Cardinals have collected a 30-17-0 record ATS this season (covering 63.8% of the time).

Cardinals hitting info

  • Jordan Walker has a team-best batting average of .299, and leads the Cardinals in home runs (13) and runs batted in (34).
  • Among hitters in MLB action, Walker ranks eighth in homers and eighth in RBI.
  • Alec Burleson has been productive as he leads his team with 34 RBI.
  • Burleson currently ranks 49th in homers and eighth in RBI in the majors.
  • Burleson enters this game on a four-game hitting streak. During his last five outings he is batting .375 with a home run and four RBIs.
  • JJ Wetherholt is batting .239 with five doubles, nine home runs and 25 walks.
  • Ivan Herrera is hitting .263 with 12 doubles, five home runs and 29 walks.
  • Herrera has safely hit in seven games in a row. During his last 10 games he is batting .326 with two doubles, a home run, a walk and six RBIs.

Cardinals pitching rankings

  • The Cardinals pitching staff ranks last in the majors with a collective 7.3 strikeouts per nine innings.
  • St. Louis has the 17th-ranked team ERA across all MLB pitching staffs (4.15).
  • Pitchers for the Cardinals combine for the 22nd-ranked WHIP in MLB (1.374).
  • The Cardinals allow the 13th-fewest home runs in baseball (49 total, one per game).
  • St. Louis struck out 13 Pirates batters while giving up 12 hits in a 9-6 win in its last game.

Pirates betting info, hitting leaders, & pitching

Pirates betting info

  • This season, the Pirates have been the underdog 19 times and won six, or 31.6%, of those games.
  • Pittsburgh has a record of 5-9 in games where sportsbooks have it as underdogs of at least +100 on the moneyline.
  • The moneyline for this contest implies a 50% chance of a victory for the Pirates.
  • So far this season, Pittsburgh and its opponents have hit the over in 26 of its 48 games with a total.
  • The Pirates are 24-24-0 against the spread this season.

Pirates hitting info

  • Brandon Lowe leads Pittsburgh with 12 home runs this season. He’s batting .252 with 31 RBI.
  • Among all batters in the majors, Lowe’s home run total is 13th, and his RBI total is 19th.
  • Oneil Cruz leads Pittsburgh in runs batted in (33) this season. He’s batting .264 while slugging .466.
  • Among all major league hitters, Cruz is 24th in home runs and 12th in RBI.
  • Cruz has hit safely in two games in a row. In his last five games he is batting .286 with a double, two walks and four RBIs.
  • Bryan Reynolds has 43 hits this season and a slash line of .253/.385/.388.
  • Spencer Horwitz has 36 hits and an OBP of .387 to go with a slugging percentage of .419 this season.
  • Horwitz has safely hit in four straight games. During his last five outings he is hitting .333 with a double and an RBI.

Pirates pitching rankings

  • The Pirates have an 8.8 K/9 this season as a pitching staff, 10th-best in baseball.
  • Pittsburgh pitchers have a combined ERA of 3.97 ERA this year, which ranks 12th in MLB.
  • The Pirates have a combined WHIP of 1.237 as a pitching staff, which ranks 11th in MLB.
  • The Pirates have given up the sixth-fewest long balls so far this season with only 43 home runs allowed.
  • Pittsburgh suffered a 9-6 defeat in its most recent game, as its pitchers struck out seven Cardinals batters while allowing nine hits.
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Betting Guide

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Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

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