The TCU Horned Frogs (6-2) host a Big 12 showdown against the Iowa State Cyclones (5-4) on Saturday, November 8, 2025 at Amon G. Carter Stadium.

The Horned Frogs are significant favorites (-7.5) in their game against the Cyclones, with the over/under being 57.5 points. (In terms of the moneyline, the Horned Frogs are -291 and the Cyclones are +236.)

Read on for our betting preview for this this game between the Horned Frogs and the Cyclones, and find all of our predictions here, too!

TCU vs. Iowa State betting lines

• Spread favorite: Horned Frogs (-7.5)
• Moneyline: Horned Frogs (-291), Cyclones (+236)
• Total: 57.5 points
• TV Channel: FOX Net (Minot-Bismarck, ND)
• Live Stream: Fubo

TCU vs. Iowa State betting info and stats

TCU has an against-the-spread record of 4-3-1 this season. TCU is 1-2 ATS when the favorite by at least 7.5 points. TCU is 5-1 in the six games this season it has been favored on the moneyline. Iowa State, in nine games with a set spread so far this season, has gone 3-5-1 against the spread. This will be the third game this year Iowa State is an underdog on the moneyline, after split the two games.

TCU vs. Iowa State recent stats and trends

TCU Horned Frogs

• TCU is 1-2 against the spread in its past three games, and has a 2-1 straight-up record in those matchups.
• The final combined score of the last three TCU games has surpassed the set total twice.
• The past three TCU games averaged 1.5 more points (59.0) than this matchup’s over/under.

Iowa State Cyclones

• Iowa State is winless against the spread in its past three games, and has a 2-1 straight-up record in those contest.
• Iowa State and its opponents have hit the over once in those games.
• Iowa State’s last three games have ended with an average of 50.0 points scored. That’s 7.5 fewer points than this contest’s over/under.

TCU vs. Iowa State key players

TCU Horned Frogs

• Josh Hoover has 2,371 passing yards for TCU, completing 64.9% of his passes and collecting 22 touchdowns and six interceptions this season.
• The team’s top rusher, Kevorian Barnes, has carried the ball 82 times for 418 yards (69.7 per game), scoring three times.
• Trent Battle has racked up 323 yards on 52 carries, scoring five times.
• Eric McAlister has hauled in 37 catches for 727 yards (90.9 yards per game) to lead the team so far this season. He’s found the end zone eight times as a receiver.
• Jordan Dwyer has grabbed 35 passes while averaging 61.8 yards per game and scoring three touchdowns.
• Joseph Manjack IV has racked up 21 grabs for 309 yards, an average of 51.5 yards per game. He’s scored two times as a receiver this season.
• Kaleb Elarms-Orr, the team’s tackle and sacks leader, has collected 4.0 sacks, 6.0 TFL and 73 tackles.
• Jamel Johnson has a team-leading four interceptions to go along with 55 tackles and four passes defended.

Iowa State Cyclones

• Rocco Becht has recored 2,119 passing yards, or 235.4 per game, so far this season. He has completed 61.9% of his passes and has collected 11 touchdowns with seven interceptions.
• The team’s top rusher, Carson Hansen, has carried the ball 113 times for 613 yards (76.6 per game) with four touchdowns.
• Abu Sama III has totaled 558 yards on 103 carries with four touchdowns.
• Brett Eskildsen has racked up 414 receiving yards on 22 receptions to pace his squad so far this season while scoring three touchdowns as a receiver.
• Benjamin Brahmer has put together a 365-yard season so far with four touchdowns. He’s caught 32 passes on 46 targets.
• Chase Sowell’s 47 targets have resulted in 22 receptions for 355 yards and one touchdown.
• Will McLaughlin paces the team with 2.0 sacks, and also has 2.0 TFL and 12 tackles.
• Marcus Neal, Iowa State’s top tackler, has 58 tackles, 7.0 TFL, one sack, and one interception this year.
• Jamison Patton has picked off a team-high two passes. He also has 43 tackles, 1.0 TFL, and two passes defended to his name.