The TCU Horned Frogs (2-0) host the SMU Mustangs (2-1) at Amon G. Carter Stadium on Saturday, September 20, 2025.

The Mustangs are underdogs, but by less than a touchdown (+6.5), versus the Horned Frogs (with an over/under of 64.5 points).

Below you can find our betting primer for this this game between the Horned Frogs and the Mustangs, and uncover all of our expert predictions here, too!

TCU vs. SMU betting lines

• Spread favorite: Horned Frogs (-6.5)
• Moneyline: Horned Frogs (-244), Mustangs (+198)
• Total: 64.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

TCU vs. SMU betting info and stats

TCU, through two games with a spread this season, is 1-1-0 against the spread. TCU is winless ATS (0-1) when favored by at least 6.5 points. TCU won the one game it played as the moneyline favorite this season. SMU, in two games with a set spread this season, is 0-2-0 against the spread. This is the first game on the year SMU is the moneyline underdog.

TCU vs. SMU key players

TCU Horned Frogs

• Josh Hoover has racked up 621 yards (310.5 ypg) on 48-of-63 passing with six touchdowns compared to one interception this season.
• Kevorian Barnes has 156 rushing yards on 21 carries with one touchdown.
• Nate Palmer has been handed the ball 13 times this year and racked up 88 yards (44.0 per game).
• Jordan Dwyer’s 225 yards as a receiver pace the team. He’s been targeted 17 times and has registered 14 catches and two touchdowns.
• Joseph Manjack IV has caught six passes for 138 yards (69.0 yards per game) this year.
• Eric McAlister has a total of 66 receiving yards so far this year, hauling in five passes.
• Ansel Din-Mbuh has 1.5 sacks to pace the team, and also has 2.0 TFL and four tackles.
• TCU’s top-tackler, Jamel Johnson, has seven tackles this year.
• Bud Clark leads the team with one interception, while also recording five tackles and one pass defended.

SMU Mustangs

• Kevin Jennings has put up 836 passing yards, or 278.7 per game, so far this season. He has completed 70.5% of his passes and has tossed six touchdowns with three interceptions.
• The team’s top rusher, Tomarion Harden, has carried the ball 42 times for 253 yards (84.3 per game) with five touchdowns.
• Chris Johnson Jr. has been given 18 carries and totaled 111 yards with one touchdown while also gaining 61 yards through the air .
• Romello Brinson has racked up 314 receiving yards on 15 catches to pace his squad so far this season while scoring three touchdowns as a receiver.
• Jalen Cooper has 12 receptions (on 18 targets) for a total of 230 yards (76.7 yards per game) and two touchdowns this year.
• RJ Maryland’s 10 targets have resulted in eight receptions for 66 yards and one touchdown.
• Jeffrey M’ba has 2.5 sacks to lead the team, and also has 2.0 TFL and four tackles.
• Ahmaad Moses is the team’s leading tackler this year. He’s totaled 11 tackles, 1.0 TFL, one sack, and one interception.
• Jaelyn Davis-Robinson leads the team with one interception, while also putting up seven tackles and one pass defended.