The Georgia Southern Eagles (0-1) visit the USC Trojans (1-0) at Los Angeles Memorial Coliseum on Saturday, September 6, 2025.

The Trojans are very heavy favorites (currently -28.5) in their matchup versus the Eagles, with the over/under at 61.5 points. (In terms of the moneyline, the Trojans are -8333 and the Eagles are +1920.)

Below you’ll find our betting preview for this this contest between the Trojans and the Eagles, and discover all of our expert predictions here, too!

USC vs. Georgia Southern betting lines

• Spread favorite: Trojans (-28.5)
• Moneyline: Trojans (-8333), Eagles (+1920)
• Total: 61.5 points
• TV Channel: FOX Sports 1
• Live Stream: Fubo

USC vs. Georgia Southern betting info and stats

USC has not lost a game against the spread this season (1-0-0). USC is undefeated ATS (1-0) when favored by at least 28.5 points. In one game as the moneyline favorite, USC won. Georgia Southern, in one game with a set spread this season, is 0-1-0 against the spread. This will be the first time on the year Georgia Southern is the moneyline underdog.

USC vs. Georgia Southern key players

USC Trojans

• Miller Moss’ previous season stat line: 2,555 passing yards (283.9 per game), 233-for-362 (64.4%), 18 touchdowns and nine picks.
• Last year, Jo’Quavious Marks ran for 1,133 yards on 198 attempts (94.4 yards per game) and scored nine times. Marks also collected 47 catches for 321 yards.
• Quinten Joyner collected 478 rushing yards on 63 carries and three touchdowns last season.
• In the previous season, Makai Lemon grabbed 52 passes (on 72 targets) for 764 yards (58.8 per game). He also found the end zone three times.
• Ja’Kobi Lane also impressed receiving last year. He collected 43 receptions for 525 yards and 12 touchdowns. He was targeted 71 times.
• Zachariah Branch hauled in 47 passes for 503 yards and one touchdown, averaging 41.9 yards per game last season.
• Easton Mascarenas-Arnold put up an impressive resume last season of 3.0 sacks, 4.0 TFL, 90 tackles, and two interceptions.
• Jaylin Smith intercepted two passes last year while also totaling 49 tackles, 3.0 TFL, and two passes defended.

Georgia Southern Eagles

• JC French connected on 65.5% of his passes and threw for 2,831 yards and 17 touchdowns last season. French also helped on the ground, tallying two touchdowns on 19.2 yards per game.
• Jalen White averaged 57.3 rushing yards per game and scored 14 rushing touchdowns.
• OJ Arnold ran for three touchdowns on 315 yards a year ago.
• Derwin Burgess Jr. was targeted 7.7 times per game and collected 659 receiving yards and three touchdowns over the course of 2024.
• Josh Dallas hauled in six touchdowns and had 614 receiving yards (47.2 ypg) in 2024.
• Dalen Cobb caught 52 passes on his way to 599 receiving yards and four touchdowns a season ago.
• Last year Davion Rhodes put pressure on opposing quarterbacks with 3.0 sacks, and added 4.0 TFL and 16 tackles.
• Marques Watson-Trent had a stellar defensive performance last season with 97 tackles, 3.0 TFL, and 1.5 sacks.
• A year ago Marc Stampley II collected 39 tackles, 1.0 TFL, two sacks, and three passes defended as well as three interceptions.