The USC Trojans (2-0) hit the road for a Big Ten clash against the Purdue Boilermakers (2-0) on Saturday, September 13, 2025 at Ross-Ade Stadium.

The Trojans are very big favorites (currently -20.5) in their matchup against the Boilermakers, with the over/under at 59.5 points. (On the moneyline, the Trojans are -1493 and the Boilermakers are +852.)

Keep reading to check out our betting primer for this this matchup between the Trojans and the Boilermakers, and uncover all of our predictions here, too!

USC vs. Purdue betting lines

• Spread favorite: Trojans (-20.5)
• Moneyline: Trojans (-1493), Boilermakers (+852)
• Total: 59.5 points
• TV Channel: CBS (KTVQ – Billings)
• Live Stream: Fubo

USC vs. Purdue betting info and stats

USC has won twice against the spread this season (2-0-0). USC has always covered the spread when it served as the favorite by at least 20.5 points (a 2-0 ATS record). USC has won both games as the moneyline favorite this season. Purdue has one win against the spread so far this season (1-1-0). Purdue has not been listed as the underdog on the moneyline yet this season.

USC vs. Purdue key players

USC Trojans

• Jayden Maiava has thrown for 707 yards (353.5 ypg) to lead USC, completing 73.8% of his passes and tossing six touchdown passes this season.
• The team’s top rusher, Waymond Jordan, has carried the ball 21 times for 209 yards (104.5 per game), scoring two times.
• King Miller has collected 135 yards on seven attempts, scoring two times.
• Makai Lemon’s leads his squad with 248 yards as a receiver. He’s racked up that yardage on 11 receptions (out of 13 targets) and scored two touchdowns.
• Ja’Kobi Lane has hauled in six receptions totaling 124 yards, finding the end zone one time as a receiver so far this campaign.
• Lake McRee’s four grabs are good enough for 106 yards and one touchdown.
• Anthony Lucas has 2.0 sacks to lead the team, and also has 2.0 TFL.
• Eric Gentry is the team’s leading tackler this year. He’s collected 1.0 TFL and one sack.
• Garrett Pomerantz has a team-high one interception to go along with one pass defended.

Purdue Boilermakers

• Ryan Browne has been a dual threat for Purdue this season. He has 481 passing yards (240.5 per game) while completing 65.3% of his passes. He’s tossed four touchdown passes and one interception this season. On the ground, he’s compiled 55 yards (27.5 ypg) on 16 carries with one rushing touchdown.
• Devin Mockobee has rushed 46 times for a team-high 185 yards (92.5 per game) with three touchdowns. He also leads the team through the air, as his four receptions this season are good for 66 yards.
• Arhmad Branch paces his team with 132 receiving yards on five catches with two touchdowns.
• Michael Jackson III has caught seven passes and compiled 79 receiving yards (39.5 per game) with one touchdown.
• CJ Nunnally has 2.0 sacks to lead the team, and also has 2.0 TFL and three tackles.
• Purdue’s top-tackler, Tahj Ra-El, has six tackles and 1.0 TFL this year.