Villanova vs. DePaul betting: College basketball preview for March 4

Data Skrive

The Villanova Wildcats (22-7, 13-5 Big East) hit the road in Big East action against the DePaul Blue Demons (16-13, 8-10 Big East) on Wednesday, March 4, 2026 at 8 p.m. ET. The Wildcats are 2.5-point favorites in the game. The over/under is set at 135.5 in the matchup.

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Villanova Cover -2.5 vs DePaul -114

Bet $20, Payout $37.54

Villanova vs. DePaul betting lines

  • Villanova moneyline odds to win: -156
  • DePaul moneyline odds to win: +126
  • Spread: Villanova (-2.5)
  • Total: 135.5

Villanova statistics, trends and more

As the away team

  • At home, Villanova sports a worse record against the spread (7-8-0) compared to its ATS record on the road (7-4-0).
  • At home, the Wildcats go over the total 60% of the time (nine of 15 games). They hit the over more often in away games, going over the total in 63.6% of games (seven of 11).
  • As a moneyline favorite, Villanova has won a lower percentage of its games when playing at home (.923) compared to road games (1.000).

Recent trends

  • In their last 10 games, the Wildcats have been putting up 75.7 points per contest, an average that’s a little lower than the 77.2 they’ve scored over the course of the 2025-26 season.
  • Villanova has been slightly suspect on the defensive end of the floor recently, allowing 74.8 points per game over its last 10 outings compared to the 70.8 it has surrendered this season.
  • The Wildcats’ past 10 contests have seen them make 9.6 three-pointers per game while shooting 34.2% from beyond the arc. Both numbers are down from their 2025-26 averages of 9.7 makes and 35.5%.

Villanova betting records this season

  • ATS Record: 17-12-0 (Home: 7-8-0; Away: 7-4-0)
  • ATS Record When Favored by 2.5+: 11-8-0 (As Favorite: 12-8-0; As Underdog: 5-4-0)
  • O-U-P: 17-12-0 (Home: 9-6-0; Away: 7-4-0)
  • Record When Moneyline Favorite: 19-1 (Home: 12-1; Away: 6-0)
  • Record When Moneyline Underdog: 3-6 (Home: 0-2; Away: 2-3)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
45.6 (158th in nation) 45.0 (230th) 30.7 (254th) 31.1 (196th) 15.3 (94th) 9.3 (34th)

Need to know more about sports betting before you put down a wager on Villanova vs. DePaul? Here’s everything you need to know about how to bet.

DePaul statistics, trends and more

As the home team

  • DePaul has performed better against the spread on the road (8-3-0) than at home (9-7-0) this season.
  • Blue Demons games have finished above the over/under more frequently at home (six times out of 16) than on the road (three of 11) this season.
  • The Blue Demons’ winning percentage at home when moneyline underdogs is .400 (2-3), and on the road it is .364 (4-7).

Recent trends

  • In their last 10 games, the Blue Demons are posting 66.5 points per game, 4.7 fewer points than their season average (71.2).
  • In its last 10 games, DePaul is ceding 67.7 points per contest, 1.5 fewer points than its season average (69.2).
  • The Blue Demons are making 7.1 three-pointers per game over their past 10 games, which is 0.2 fewer three-pointers than their average for the season (7.3). Additionally, they sport a lower three-point percentage over their previous 10 games (31.6%) compared to their season average from downtown (33.0%).

DePaul betting records this season

  • ATS Record: 18-11-0 (Home: 9-7-0; Away: 8-3-0)
  • ATS Record When Underdog by 2.5+: 10-6-0 (As Favorite: 7-5-0; As Underdog: 11-6-0)
  • O-U-P: 10-19-0 (Home: 6-10-0; Away: 3-8-0)
  • Record When Moneyline Favorite: 10-2 (Home: 9-2; Away: 0-0)
  • Record When Moneyline Underdog: 6-11 (Home: 2-3; Away: 4-7)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
44.0 (258th in nation) 43.4 (121st) 30.6 (260th) 30.3 (136th) 15.2 (100th) 11.1 (205th)
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