ACC foes match up when the Virginia Tech Hokies (2-3) and the Wake Forest Demon Deacons (2-2) play on Saturday, October 4, 2025 at Lane Stadium.

The Hokies are favored, but by less than a touchdown (-6), versus the Demon Deacons. The over/under for this matchup is 51.5 points.

Read on for our betting primer for this this game between the Hokies and the Demon Deacons, and uncover all of our betting picks here, too!

Virginia Tech vs. Wake Forest betting lines

• Spread favorite: Hokies (-6)
• Moneyline: Hokies (-227), Demon Deacons (+187)
• Total: 51.5 points
• TV Channel: CW (WGN – Chicago)
• Live Stream: Fubo

Virginia Tech vs. Wake Forest betting info and stats

Virginia Tech has won once against the spread this season (1-4-0). Virginia Tech is winless ATS (0-1) when favored by at least 6 points. Virginia Tech has been named as moneyline favorites three times this season, and has put up a 1-2 record in those games. Wake Forest, in four games with a set spread this season, is 2-2-0 against the spread. In the two games Wake Forest has been an underdog by at least 6 points, it covered the spread once. Wake Forest has been an underdog on the moneyline in two games so far this season, and it lost both games.

Virginia Tech vs. Wake Forest recent stats and trends

Virginia Tech Hokies

• Virginia Tech is 1-2 against the spread in its past three games, and has a 2-1 straight-up record in those contests.
• The final combined score of the past three Virginia Tech games surpassed the set total one time.
• The last three Virginia Tech games averaged 53.3 total points, 1.8 more points than this matchup’s point total.

Wake Forest Demon Deacons

Virginia Tech vs. Wake Forest key players

Virginia Tech Hokies

• Kyron Drones has thrown for 1,105 yards (221.0 ypg) to lead Virginia Tech, completing 62.1% of his passes and recording eight touchdown passes compared to three interceptions this season. He’s also figured in the ground game with 158 rushing yards on 63 carries with four rushing touchdowns.
• Terion Stewart has racked up 239 yards on 26 carries.
• This season, Marcellous Hawkins has carried the ball 44 times for 234 yards (46.8 per game).
• Ayden Greene’s team-leading 244 yards as a receiver have come on 15 receptions (out of 33 targets) with one touchdown.
• Donavon Greene has reeled in 12 passes while averaging 43.0 yards per game and scoring two touchdowns.
• Cameron Seldon has hauled in 16 catches for 110 yards, an average of 22.0 yards per game. He’s scored one time as a receiver this season.
• Kelvin Gilliam leads the team with 2.0 sacks, and also has 1.0 TFL and 11 tackles.
• Isaiah Cash, Virginia Tech’s leading tackler, has 22 tackles, 1.0 TFL, and one sack this year.
• Kemari Copeland has a team-high one interception to go along with 17 tackles, one sack, and one pass defended.

Wake Forest Demon Deacons

• Robby Ashford has thrown for 916 yards (229.0 ypg) to lead Wake Forest, completing 59.3% of his passes and recording one touchdown pass and three interceptions this season. He is also a playmaker on the ground, racking up 211 yards (52.8 ypg) on 44 carries with four touchdowns.
• Demond Claiborne has rushed 46 times for 366 yards, with six touchdowns.
• Chris Barnes has collected 15 receptions this season and his team-high yardage total sits at 287 (71.8 yards per game). He’s been targeted 22 times.
• Sterling Berkhalter has 10 receptions (on 15 targets) for a total of 199 yards (49.8 yards per game) and one touchdown this year.
• Eni Falayi has racked up 133 reciving yards (44.3 ypg) this season.
• Langston Hardy has 2.5 sacks to lead the team, and also has 3.0 TFL and 21 tackles.
• Nick Andersen, Wake Forest’s tackle leader, has 35 tackles and 1.0 TFL this year.
• Zamari Stevenson leads the team with one interception, while also putting up 11 tackles and one pass defended.