Orioles vs. White Sox Betting Lines, Odds, & Player Matchups September 15, 2025

Data Skrive
Data Skrive

The Baltimore Orioles (69-79) have lost two games in a row as they prepare to take on the Chicago White Sox (57-92), who have also dropped two in a row. The Orioles are favored (-141) to stop their streak in Monday’s outing, which starts at 7:40 p.m. ET at Rate Field. Baltimore’s Tyler Wells and Chicago’s Sean Burke will take the mound first.

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Odds to Win

Orioles to win vs White Sox -141

Bet $20, Payout $34.18

Orioles vs. White Sox betting lines

  • Favorite: Orioles (-141)
  • Underdog: White Sox (+119)
  • Over/under: 8.5

Orioles betting info, hitting leaders, & pitching

Orioles betting info

  • The Orioles have a 31-33 record in games they were listed as the moneyline favorite (winning 48.4% of those games).
  • In games it has played as moneyline favorites with odds of -141 or shorter, Baltimore has a record of 12-10 (54.5%).
  • Based on this matchup’s moneyline, the Orioles have an implied win probability of 58.5%.
  • In the 148 games in which bookmakers have set an over/under for Baltimore, it has combined with opponents to go over the total 61 times (61-82-5).
  • The Orioles are 71-77-0 against the spread this season.

Orioles hitting info

  • Gunnar Henderson has put up a team-best batting average of .270 and leads the Orioles in runs batted in (62).
  • Among hitters in MLB play, Henderson ranks 112th in homers and 97th in RBI.
  • Jackson Holliday’s 17 home runs are a team-high mark.
  • Holliday currently ranks 100th in homers and 128th in RBI in the bigs.
  • Holliday brings a six-game hitting streak into this game. In his last 10 outings he is hitting .342 with a double, two home runs, seven walks and four RBIs.
  • Ryan Mountcastle is hitting .256 with 18 doubles, five home runs and 14 walks.
  • Colton Cowser is batting .201 with 12 doubles, 13 home runs and 22 walks.

Orioles pitching rankings

  • The pitching staff for the Orioles has a collective 8.4 K/9, which ranks 16th in the majors.
  • Baltimore has a 4.59 team ERA that ranks 24th across all MLB pitching staffs.
  • The Orioles average baseball’s fourth-highest WHIP (1.373).
  • Orioles pitchers combine to surrender 198 total home runs at a clip of 1.3 per game (fourth-most in MLB).
  • Baltimore lost to the Blue Jays 5-4 in its last game with five strikeouts while allowing 12 hits.

White Sox betting info, hitting leaders, & pitching

White Sox betting info

  • This season, the White Sox have won 56 out of the 147 games, or 38.1%, in which they’ve been the underdog.
  • Chicago has a record of 40-73, a 35.4% win rate, when it’s set as an underdog of +119 or more by sportsbooks this season.
  • The implied probability of a win by the White Sox, based on the moneyline, is 45.7%.
  • So far this season, Chicago and its opponents have hit the over in 68 of its 149 games with a total.
  • The White Sox have an ATS record of 87-62-0 in 149 games with a spread this season.

White Sox hitting info

  • Miguel Vargas has been key for Chicago with 14 home runs, 52 RBI and a batting average of .229 this season.
  • Among all hitters in the majors, Vargas’ home run total is 141st, and his RBI total is 141st.
  • Andrew Benintendi has collected 100 hits this season and has an OBP of .306. He’s slugging .431 on the year.
  • Benintendi ranks 79th overall in homers and 106th in RBI this season.
  • Lenyn Sosa leads Chicago in home runs with 20, runs batted in with 68 and his batting average of .263 is also best on his team.
  • Chase Meidroth is batting .269 with an OBP of .347 and a slugging percentage of .337 this season.
  • Meidroth heads into this matchup on a nine-game hitting streak. In his last 10 outings he is batting .429 with a double, five walks and an RBI.

White Sox pitching rankings

  • The White Sox average the 22nd-most strikeouts per nine innings (8.0) in the majors this season.
  • Chicago pitchers have a combined ERA of 4.23 ERA this year, which ranks 20th in MLB.
  • White Sox pitchers have a 1.361 WHIP this season, 25th in the majors.
  • The White Sox have allowed the 14th-fewest home runs this season with 170, or 1.1 per game.
  • Last time out, Chicago fell to the Guardians 3-1. Its pitchers compiled six strikeouts and six hits allowed.
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