College Football Week 4 Best Games

Data Skrive
Data Skrive

The Week 4 college football schedule features plenty of excitement, including the matchup between the Michigan Wolverines and the Nebraska Cornhuskers.

Here is what you need to know in terms of
the betting odds for Week 4 in college football.

Below you can find our betting previews for this season, and uncover all of our betting picks here, too!

Week 4’s Closest Projected College Football Games (by Spread)

No. 21 Michigan (3-1) at Nebraska (3-1)

View Betting Preview

  • Game Time: 3:30 p.m. ET | Saturday, September 20, 2025
  • Nebraska Last Game: 30-27 L vs Michigan
  • Michigan Last Game: 30-27 W vs Nebraska
To Cover the Spread

Michigan -1 vs. Nebraska

Bet $20, Payout $39.42

Rice (3-1) at Charlotte (1-3)

View Betting Preview

  • Game Time: 7:30 p.m. ET | Thursday, September 18, 2025
  • Charlotte Last Game: 28-17 L vs Rice
  • Rice Last Game: 28-17 W vs Charlotte
Betting Odds

Rice -1.5 vs. Charlotte

Bet $20, Payout $38.02

UNLV (4-0) at Miami (OH) (0-3)

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  • Game Time: 12 p.m. ET | Saturday, September 20, 2025
  • Miami (OH) Last Game: 41-38 L vs UNLV
  • UNLV Last Game: 41-38 W vs Miami (OH)
Betting Odds

UNLV -1.5 vs. Miami (OH)

Bet $20, Payout $37.86

Arizona State (2-1) at Baylor (2-1)

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  • Game Time: 7:30 p.m. ET | Saturday, September 20, 2025
  • Baylor Last Game: 42-7 W vs Samford
  • ASU Last Game: 34-15 W vs Texas State
Betting Odds

Baylor -2.5 vs. Arizona State

Bet $20, Payout $37.70

Marshall (1-2) at Middle Tennessee (1-2)

View Betting Preview

  • Game Time: 7 p.m. ET | Saturday, September 20, 2025
  • MTSU Last Game: 14-13 W vs Nevada
  • Marshall Last Game: 38-7 W vs Eastern Kentucky
Spread

Marshall -2.5 vs. Middle Tennessee

Bet $20, Payout $37.70

Louisiana (1-3) at Eastern Michigan (1-3)

View Betting Preview

  • Game Time: 3:30 p.m. ET | Saturday, September 20, 2025
  • EMU Last Game: 34-31 W vs Louisiana
  • Louisiana Last Game: 34-31 L vs Eastern Michigan
To Cover the Spread

Louisiana -2.5 vs. Eastern Michigan

Bet $20, Payout $38.35

Fresno State (3-1) at Hawaii (3-1)

View Betting Preview

  • Game Time: TBA ET | Sunday, September 21, 2025
  • Hawaii Last Game: 23-3 W vs Portland State
  • Fresno State Last Game: 56-7 W vs Southern University
Spread

Fresno State -2.5 vs. Hawaii

Bet $20, Payout $37.86

Iowa (3-1) at Rutgers (3-1)

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  • Game Time: 8 p.m. ET | Friday, September 19, 2025
  • Rutgers Last Game: 38-28 L vs Iowa
  • Iowa Last Game: 38-28 W vs Rutgers
To Cover the Spread

Iowa -2.5 vs. Rutgers

Bet $20, Payout $38.18

North Texas (4-0) at Army (1-2)

View Betting Preview

  • Game Time: 12 p.m. ET | Saturday, September 20, 2025
  • Army Last Game: 45-38 L vs North Texas
  • North Texas Last Game: 45-38 W vs Army
To Cover the Spread

North Texas -2.5 vs. Army

Bet $20, Payout $37.39

North Carolina State (3-1) at Duke (2-2)

View Betting Preview

  • Game Time: 4 p.m. ET | Saturday, September 20, 2025
  • Duke Last Game: 45-33 W vs North Carolina State
  • NC State Last Game: 45-33 L vs Duke
Spread

Duke -3 vs. North Carolina State

Bet $20, Payout $38.69
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Ryan Knuppel

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Betting Guide

How Money Line Works?

Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

When we, as sports fans, learned our multiplication tables, we aced the number 7. Seven, 14, 21, 28, 35, 42 were easy because we all watched football on the weekends. Multiplication by sevens, then add a three, a six after a missed PAT.

How to Bet on NFL Games

Baseball is America’s pastime, but football is America’s crazed passion, with its weekly schedule of games, millions of television viewers across the country and the world, and the billion-dollar stadiums that serve as Sunday cathedrals in 32 American cities.

What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …