Cubs vs. Cardinals Betting Lines, Odds, & Player Matchups September 28, 2025

Data Skrive
Data Skrive

Michael Busch leads the Chicago Cubs (91-70) into a contest with the St. Louis Cardinals (78-83) after he homered twice in a 7-3 win over the Cardinals. The Cubs are favored on the moneyline (-164) against the Cardinals (+138) in this outing, which begins at 3:20 p.m. ET on Sunday. Javier Assad gets the starting nod for Chicago, and Kyle Leahy is St. Louis’ pick to start.

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Moneyline

Cubs to win vs Cardinals -164

Bet $20, Payout $32.20

Cubs vs. Cardinals betting lines

  • Favorite: Cubs (-164)
  • Underdog: Cardinals (+138)
  • Over/under: 8.5

Cubs betting info, hitting leaders, & pitching

Cubs betting info

  • The Cubs have won 63.5% of the games this season when they were favored on the moneyline (73-42).
  • Chicago has gone 31-15 (winning 67.4% of its games) when it has played as moneyline favorites of -164 or shorter.
  • The Cubs have a 62.1% chance to win this matchup based on the moneyline’s implied probability.
  • In the 161 games in which bookmakers have set an over/under for Chicago, it has combined with opponents to go over the total 75 times (75-76-10).
  • The Cubs have a 76-85-0 record against the spread this season.

Cubs hitting info

  • Kyle Tucker is hitting .268 with 25 doubles, four triples, 22 home runs and 87 walks.
  • Tucker’s home runs rank 65th in MLB and he ranks 74th in RBI in MLB.
  • Nico Hoerner’s .297 batting average paces his team.
  • Hoerner ranks 264th in homers and 123rd in RBI among hitters in MLB action.
  • Pete Crow-Armstrong is hitting .247 with 37 doubles, four triples, 31 home runs and 29 walks.
  • Crow-Armstrong takes a three-game hitting streak into this matchup. In his last five games he is hitting .294 with two home runs and five RBIs.
  • Busch has shown his power as he paces his team with 34 home runs.
  • Busch takes a two-game hitting streak into this game. During his last five outings he is hitting .471 with three doubles, a triple, four home runs, four walks and eight RBIs.

Cubs pitching rankings

  • The pitching staff for the Cubs has a collective 7.9 K/9, the fifth-worst in MLB.
  • Chicago has a 3.82 team ERA that ranks eighth among all MLB pitching staffs.
  • Pitchers for the Cubs combine for the No. 2-ranked WHIP in the majors (1.180).
  • Cubs pitchers combine to allow the 24th-fewest home runs in baseball (202 total, 1.3 per game).
  • In its 7-3 win last time out, Chicago struck out 13 Cardinals batters while allowing seven hits.

Cardinals betting info, hitting leaders, & pitching

Cardinals betting info

  • The Cardinals have entered the game as underdogs 92 times this season and won 44, or 47.8%, of those games.
  • St. Louis has entered 27 games this season as the underdog by +138 or more and is 9-18 in those contests.
  • The oddsmakers’ moneyline implies a 42% chance of a victory for the Cardinals.
  • Games involving St. Louis have gone over the total set by oddsmakers in 81 of 160 chances this season.
  • The Cardinals are 81-79-0 against the spread in their 160 chances this season.

Cardinals hitting info

  • Alec Burleson leads St. Louis in batting average (.290) this season while adding 18 home runs and 69 RBI.
  • In all of MLB, Burleson ranks 105th in homers and 89th in RBI.
  • Brendan Donovan is batting .287 with an OBP of .353 and a slugging percentage of .422 this season.
  • Donovan is 215th overall in homers and 178th in RBI this season.
  • Donovan enters this matchup on an eight-game hitting streak. During his last 10 outings he is hitting .348 with seven doubles, a home run, two walks and five RBIs.
  • Ivan Herrera has 110 hits this season and a slash line of .286/.377/.469.
  • Herrera brings an eight-game hitting streak into this matchup. During his last 10 outings he is batting .314 with three home runs, six walks and eight RBIs.
  • Lars Nootbaar has collected 119 hits this season and has an OBP of .325. He’s slugging .361 on the year.

Cardinals pitching rankings

  • The Cardinals strike out just 7.6 batters per nine innings as a pitching staff, which ranks 29th in MLB.
  • St. Louis pitchers have a combined ERA of 4.31 ERA this year, which ranks 20th in MLB.
  • Cardinals pitchers have a 1.327 WHIP this season, 24th in the majors.
  • The Cardinals have given up the seventh-fewest long balls so far this season with only 169 home runs allowed.
  • St. Louis suffered a 7-3 defeat in its most recent game, as its pitchers struck out eight Cubs batters while allowing 10 hits.
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Betting Guide

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Moneyline betting is by far the easiest way to place a sports wager. There are no point spreads to parse, no garbage-time free throws to ruin your betting day, and no last-minute meaningless touchdowns to take you from a winner to a loser.

How to Bet Odds

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What is the Spread?

If you are a golfer or have ever played on a bowling team, think of a point spread like a handicap. It is a way for two teams of differing abilities to play each other on equal footing.  The better team, and the favorite in the game, gives a certain amount …