The Clemson Tigers and the Penn State Nittany Lions play in the Pinstripe Bowl on December 27, 2025.

The Tigers are favored, but by less than a field goal (-2.5), versus the Nittany Lions. The over/under for this matchup is 47.5 points.

Keep reading to check out our betting preview for this this matchup between the Tigers and the Nittany Lions, and uncover all of our predictions here, too!

Clemson vs. Penn State betting lines

• Spread favorite: Tigers (-2.5)
• Moneyline: Tigers (-143), Nittany Lions (+121)
• Total: 47.5 points
• TV Channel: ESPN2
• Live Stream: Fubo

Clemson vs. Penn State betting info and stats

Clemson has won five games against the spread this season (5-7-0). Clemson has covered the spread two times when the favorite by at least 2.5 points (a 2-7 ATS record). Clemson has recorded a 4-5 record in the nine games this season it has been the moneyline favorite. Penn State has won four games against the spread so far this season (4-8-0). In the three games Penn State has been the underdog by at least 2.5 points, it covered the spread twice. Penn State is winless in the three games it has been listed as an underdog on the moneyline this season.

Clemson vs. Penn State recent stats and trends

Clemson Tigers

• Clemson is 2-1 against the spread and 3-0 overall in its past three matchups.
• In each of those games, the final combined score fell short of the set total.
• The past three Clemson games averaged 3.7 more points (51.2) than this matchup’s over/under.

Penn State Nittany Lions

• Penn State is 2-1 against the spread in its last three games and has a 3-0 straight-up record in those matchups.
• Penn State and its opponents have hit the over two times in those games.
• Penn State’s last three outings have ended with an average of 49.8 points scored. That’s 2.3 more points than this contest’s over/under.

Clemson vs. Penn State key players

Clemson Tigers

• Cade Klubnik has thrown for 2,750 yards (250.0 ypg) to lead Clemson, completing 66.6% of his passes and recording 16 touchdown passes compared to six interceptions this season.
• Adam Randall has carried the ball 157 times for a team-high 779 yards on the ground and has found the end zone nine times as a runner. He’s also tacked on 31 catches for 246 yards (22.4 per game) and three touchdowns in the pass game.
• Gideon Davidson has been handed the ball 56 times this year and racked up 249 yards (24.9 per game). He’s also helped out in the pass game with 10 grabs for 80 yards
• T.J. Moore has hauled in 46 catches for 754 yards (62.8 yards per game) to lead the team so far this season. He’s found the end zone four times as a receiver.
• Antonio Williams has hauled in 55 receptions totaling 604 yards, finding the end zone four times as a receiver so far this campaign.
• Bryant Wesco Jr.’s 31 catches are good enough for 537 yards and six touchdowns.
• Will Heldt leads the team with 6.5 sacks, and also has 11.0 TFL and 39 tackles.
• Sammy Brown is the team’s leading tackler this year. He’s collected 83 tackles, 9.0 TFL, five sacks, and one interception.
• Ricardo Jones has a team-high six interceptions to go along with 33 tackles, 1.0 TFL, and six passes defended.

Penn State Nittany Lions

• Drew Allar leads Penn State with 1,100 yards on 103-of-159 passing with eight touchdowns compared to three interceptions this season. He has chipped in with 172 rushing yards (28.7 ypg) on 36 carries while scoring one touchdown on the ground.
• Kaytron Allen has run the ball 210 times for 1,303 yards, with 15 touchdowns.
• Nicholas Singleton has racked up 549 yards on 123 carries with 13 touchdowns, while also catching 24 passes for 219 yards and one score.
• Trebor Pena’s 452 receiving yards (37.7 yards per game) lead the team. He has 44 receptions on 61 targets with one touchdown.
• Devonte Ross has totaled 417 receiving yards (34.8 yards per game) and five touchdowns on 28 receptions.
• Kyron Ware-Hudson’s 50 targets have resulted in 23 grabs for 288 yards and two touchdowns.
• Dani Dennis-Sutton has 6.5 sacks to pace the team, and also has 8.0 TFL and 37 tackles.
• Amare Campbell is the team’s top-tackler this year. He’s totaled 97 tackles, 8.0 TFL, and three sacks.
• Zane Durant has picked off a team-leading one pass. He also has 24 tackles, 4.0 TFL, four sacks, and one pass defended to his name.