The Clemson Tigers (1-2) and the Syracuse Orange (2-1) square off on Saturday, September 20, 2025 at Memorial Stadium (Clemson, SC) in a battle of ACC foes.
The Tigers are expected to come out on top by at least two touchdowns (currently -17) versus the Orange. The over/under for this matchup is 54.5 points.
Below you can find our betting preview for this this matchup between the Tigers and the Orange, and uncover all of our expert picks here, too!
To Cover the Spread
Bet $20, Payout $38.18
Clemson -17 vs. Syracuse
Clemson vs. Syracuse betting lines
- Spread favorite: Tigers (-17)
- Moneyline: Tigers (-855), Orange (+576)
- Total: 54.5 points
- TV Channel: ESPN
- Live Stream: Fubo
Clemson vs. Syracuse betting info and stats
- Clemson, through three games with a spread so far this season, has gone 0-3-0 against the spread. Clemson is winless ATS (0-1) when the favorite by at least 17 points. Clemson has put together a 1-2 record in the three games this season it has been moneyline favorites. Syracuse has a single win against the spread so far this season (1-1-1). This will be the second time this year Syracuse is the moneyline underdog. The Orange lost the first one.
Clemson vs. Syracuse key players
Clemson Tigers
- Cade Klubnik leads Clemson with 633 yards (211 ypg) on 52-of-88 passing with three touchdowns and three interceptions this season. He also has 59 rushing yards on 30 carries while scoring one touchdown on the ground.
- The team’s top rusher, Adam Randall, has carried the ball 41 times for 208 yards (69.3 per game), scoring three times. He’s also caught six passes for 37 yards.
- Bryant Wesco Jr. has hauled in 18 catches for 310 yards (103.3 yards per game) to lead the team so far this season. He’s found the end zone three times as a receiver.
- Tyler Brown has caught 10 passes while averaging 31.7 yards per game.
- T.J. Moore has a total of 72 receiving yards so far this year, hauling in seven throws.
- Will Heldt has collected two sacks to lead the team, while also picking up five TFL and 12 tackles.
- Clemson’s top-tackler, Ronan Hanafin, has 28 tackles and one interception this year.
- Ricardo Jones has a team-high one interception to go along with 13 tackles, one TFL, and one pass defended.
Syracuse Orange
- Steve Angeli has put up 1,108 passing yards, or 369.3 per game, so far this season. He has completed 64% of his passes and has tossed eight touchdowns with two interceptions.
- Yasin Willis has rushed for 139 yards on 34 carries so far this year while scoring four times on the ground.
- Will Nixon has racked up 30 carries and totaled 129 yards with one touchdown while also gaining 76 yards through the air .
- Darrell Gill Jr. paces his squad with 269 receiving yards on 12 receptions with two touchdowns.
- Dan Villari has 16 receptions (on 20 targets) for a total of 199 yards (66.3 yards per game) this year.
- Justus Ross-Simmons has racked up 159 reciving yards (53 ypg) and three touchdowns this season.
- Jamie Tremble has collected one sack to lead the team, while also picking up one TFL.
- Darian Chestnut, Syracuse’s top tackler, has 21 tackles this year.
- Demetres Samuel Jr. has a team-leading one interception to go along with 13 tackles and one pass defended.
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BetDecider Team
The BetDecider team brings you the most current sports betting content, with expert insights and tips. Our aim is that you can make an informed betting decision, including best odds and exclusive sportsbook offers, to maximize your betting experience.
