The No. 1 seed Duke Blue Devils (32-2) and the No. 16 seed Siena Saints (23-11) will meet in the opening round of the NCAA Tournament on Thursday at 2:50 p.m. ET. Duke is favored by 28.5 points in the contest, which airs on CBS. Here’s everything you need to know about this 1-16 matchup when filling out your brackets. The matchup has an over/under of 136.5.
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Duke Cover -28.5 vs Siena -109
Duke vs. Siena betting lines
- Duke moneyline odds to win: -50000
- Siena moneyline odds to win: +4300
- Spread: Duke (-28.5)
- Total: 136.5
Duke statistics, trends and more
Recent trends
- The Blue Devils have been putting up 80.9 points per contest in their last 10 appearances, an average that’s slightly lower than the 82.3 they’ve scored over the course of the 2025-26 campaign.
- Duke’s defense has been more stingy lately, as the team has given up 62.3 points per game over its past 10 compared to the 63.1 points per game its opponents average this season.
- The Blue Devils’ last 10 outings have seen them make 10 three-pointers per game while shooting 37.3% from deep. Both numbers are up from their 2025-26 averages of 9.1 makes and 35.1%.
Duke betting records this season
- ATS Record: 19-15-0 (Home: 7-8-0; Away: 8-3-0)
- ATS Record When Favored by 28.5+: 3-3-0 (As Favorite: 18-15-0; As Underdog: 1-0-0)
- O-U-P: 11-23-0 (Home: 4-11-0; Away: 4-7-0)
- Record When Moneyline Favorite: 28-2 (Home: 13-0; Away: 9-1)
- Record When Moneyline Underdog: 1-0 (Home: 0-0; Away: 0-0)
| Field Goal % | Opp. Field Goal % | Rebounds | Opp. Rebounds | Assists | Turnovers |
|---|---|---|---|---|---|
| 49 (22nd in nation) | 39.2 (eighth) | 37.4 (eighth) | 26.5 (seventh) | 16.7 (35th) | 10.2 (102nd) |
Need to know more about sports betting before you put down a wager on Duke vs. Siena? Here’s everything you need to know about how to bet.
Siena statistics, trends and more
Recent trends
- The Saints are putting up 67.5 points per game over their past 10 games, which is three fewer points than their average for the season (70.5).
- In its previous 10 games, Siena is surrendering 65.5 points per contest, compared to its season average of 65.7 points allowed.
- Over their last 10 games, the Saints are draining 4.6 treys per game, 0.8 fewer threes than their season average (5.4). They also own a lower three-point percentage over their last 10 contests (27.7%) compared to their season average (30.4%).
Siena betting records this season
- ATS Record: 20-14-0 (Home: 7-6-0; Away: 9-7-0)
- O-U-P: 11-23-0 (Home: 4-9-0; Away: 7-9-0)
- Record When Moneyline Favorite: 21-7 (Home: 9-4; Away: 8-3)
- Record When Moneyline Underdog: 2-4 (Home: 0-0; Away: 1-4)
| Field Goal % | Opp. Field Goal % | Rebounds | Opp. Rebounds | Assists | Turnovers |
|---|---|---|---|---|---|
| 45.7 (148th in nation) | 42.2 (64th) | 31 (239th) | 28.7 (45th) | 13.4 (210th) | 9.7 (54th) |
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