An opening-round NCAA Tournament matchup will see the 6-seed Louisville Cardinals (23-10) hit the court as a 3.5-point favorite against the No. 11 seed South Florida Bulls (25-8) on Thursday at KeyBank Center. The matchup starts at 1:30 p.m. ET on TNT. Here’s a deep dive into this 6-11 matchup before filling out your brackets. The matchup has an over/under of 161.5 points.
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Louisville Cover -3.5 vs South Florida -121
Louisville vs. South Florida betting lines
- Louisville moneyline odds to win: -185
- South Florida moneyline odds to win: +149
- Spread: Louisville (-3.5)
- Total: 161.5
Louisville statistics, trends and more
Recent trends
- The Cardinals have been racking up 82.5 points per contest in their last 10 times on the court, an average that’s slightly lower than the 84.8 they’ve scored over the course of the 2025-26 season.
- Louisville has been more porous on the defensive side of the ball lately, allowing 75.7 points per game over its past 10 outings compared to the 72.2 points per game its opponents average on the 2025-26 season.
- During their last 10 contests, the Cardinals are making the same number of three-pointers per game as their season long average (11.5), while shooting a higher percentage from deep in that span (38.7% compared to 35.7% season-long).
Louisville betting records this season
- ATS Record: 16-17-0 (Home: 10-7-0; Away: 3-8-0)
- ATS Record When Favored by 3.5+: 15-11-0 (As Favorite: 15-14-0; As Underdog: 1-3-0)
- O-U-P: 13-20-0 (Home: 6-11-0; Away: 6-5-0)
- Record When Moneyline Favorite: 21-7 (Home: 14-1; Away: 3-5)
- Record When Moneyline Underdog: 1-3 (Home: 0-1; Away: 1-2)
| Field Goal % | Opp. Field Goal % | Rebounds | Opp. Rebounds | Assists | Turnovers |
|---|---|---|---|---|---|
| 47.1 (64th in nation) | 42.4 (72nd) | 36.1 (24th) | 30.2 (118th) | 17.1 (24th) | 11.3 (222nd) |
Need to know more about sports betting before you put down a wager on Louisville vs. South Florida? Here’s everything you need to know about how to bet.
South Florida statistics, trends and more
Recent trends
- Over their last 10 games, the Bulls are putting up 81.6 points per game, 6.1 fewer points than their season average (87.7).
- Over its last 10 games, South Florida is giving up 66.5 points per contest, 9.0 fewer points than its season average (75.5).
- Over their past 10 games, the Bulls are making 8.7 treys per contest, 0.9 fewer threes than their season average (9.6). They also have a worse three-point percentage over their past 10 contests (32.0%) compared to their season average (33.2%).
South Florida betting records this season
- ATS Record: 18-14-0 (Home: 9-5-0; Away: 7-5-0)
- ATS Record When Underdog by 3.5+: 1-1-0 (As Favorite: 16-12-0; As Underdog: 2-2-0)
- O-U-P: 14-18-0 (Home: 5-9-0; Away: 7-5-0)
- Record When Moneyline Favorite: 23-5 (Home: 12-2; Away: 8-1)
- Record When Moneyline Underdog: 1-3 (Home: 0-0; Away: 1-2)
| Field Goal % | Opp. Field Goal % | Rebounds | Opp. Rebounds | Assists | Turnovers |
|---|---|---|---|---|---|
| 43.9 (258th in nation) | 41.3 (39th) | 37.7 (sixth) | 32.6 (277th) | 17.1 (24th) | 10.8 (172nd) |
BetDecider Team
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