Duke vs. St. John’s betting: March Madness Sweet 16 preview for March 27

Data Skrive

A Sweet 16 NCAA Tournament matchup between the No. 1 Duke Blue Devils (34-2) and No. 5 St. John’s Red Storm (30-6) will determine one of the squads heading to the East Region bracket final when it tips off on Friday at Capital One Arena, beginning at 7:10 p.m. ET, airing on CBS. Oddsmakers think Duke will emerge victorious in this one, naming the as 6.5-point favorites. The over/under is set at 140.5 for the matchup.

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Duke vs. St. John’s betting lines

  • Duke moneyline odds to win: -292
  • St. John’s moneyline odds to win: +230
  • Spread: Duke (-6.5)
  • Total: 140.5

Duke statistics, trends and more

Recent trends

  • The Blue Devils’ offense has been less productive over their last 10 games, scoring 79.3 points a contest compared to the 81.9 they’ve averaged this year.
  • Duke has been a little improved on the defensive end of the floor recently, allowing 62.8 points per game over its last 10 outings compared to the 63.1 it has conceded per game this season.
  • While the Blue Devils are making more threes per game over their past 10 contests (9 per game) in comparison to their season-long average (8.9), they are doing so while shooting a lower percentage (33.8% from deep over the last 10, 34.6% on the season).

Duke betting records this season

  • ATS Record: 20-16-0 (Home: 7-8-0; Away: 8-3-0)
  • ATS Record When Favored by 6.5+: 17-16-0 (As Favorite: 19-16-0; As Underdog: 1-0-0)
  • O-U-P: 11-25-0 (Home: 4-11-0; Away: 4-7-0)
  • Record When Moneyline Favorite: 30-2 (Home: 13-0; Away: 9-1)
  • Record When Moneyline Underdog: 1-0 (Home: 0-0; Away: 0-0)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
48.9 (25th in nation) 39 (sixth) 37.5 (eighth) 26.4 (seventh) 16.6 (38th) 10.3 (114th)

Need to know more about sports betting before you put down a wager on Duke vs. St. John’s? Here’s everything you need to know about how to bet.

St. John’s statistics, trends and more

Recent trends

  • Over their last 10 games, the Red Storm are putting up 73.5 points per contest, compared to their season average of 81.1.
  • While St. John’s is allowing 69.4 points per game in 2025-26, it has improved that mark in its last 10 games, allowing 62.5 points per contest.
  • Over their last 10 games, the Red Storm are making 6.6 three-pointers per game, 0.5 fewer threes than their season average (7.1). They also sport a lower three-point percentage over their last 10 games (30%) compared to their season average (33.2%).

St. John’s betting records this season

  • ATS Record: 21-15-0 (Home: 8-9-0; Away: 7-3-0)
  • O-U-P: 14-22-0 (Home: 6-11-0; Away: 5-5-0)
  • Record When Moneyline Favorite: 28-3 (Home: 14-2; Away: 9-0)
  • Record When Moneyline Underdog: 2-3 (Home: 1-0; Away: 0-1)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
45.2 (176th in nation) 42 (59th) 34.9 (44th) 30.5 (133rd) 16.1 (51st) 9.9 (71st)
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About Ryan Knuppel

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