OVC foes square off when the Eastern Illinois Panthers (11-17, 7-10 OVC) host the Southern Indiana Screaming Eagles (6-21, 3-14 OVC) at Lantz Arena, beginning at 4:30 p.m. ET on Saturday, February 21, 2026. The Screaming Eagles are 4.5-point underdogs in the game. The point total is set at 134.5 for the matchup.

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Eastern Illinois vs. Southern Indiana betting lines

• Eastern Illinois moneyline odds to win: -208
• Southern Indiana moneyline odds to win: +167
• Spread: Eastern Illinois (-4.5)
• Total: 134.5

Eastern Illinois statistics, trends and more

As the home team

• Eastern Illinois has covered the spread in a lower percentage of its home games than away games. It has covered five times in 11 games at home, and it has covered eight times in 14 games on the road.
• The Panthers have gone over the over/under more often at home, hitting the over in five of 11 home matchups (45.5%). In away games, they have hit the over in six of 14 games (42.9%).
• Eastern Illinois has won a higher percentage of its matchups as a moneyline favorite when playing at home, going 1-0 (1.000). On the road as a moneyline favorite, it has a record of 0-1 (.000).

Recent trends

• The Panthers’ offense has been improved over their last 10 games, racking up 70.5 points per contest compared to the 67.3 they’ve averaged this year.
• Eastern Illinois’ defense has been tougher as of late, as the team has allowed 68.1 points per game over its past 10 compared to the 70.4 points per game its opponents average on the season.
• The Panthers’ last 10 contests have seen them make 5.7 three-pointers per game while shooting 34.3% from beyond the arc. Both numbers are up from their 2025-26 averages of 5.6 makes and 32.0%.

Eastern Illinois betting records this season

• ATS Record: 13-12-0 (Home: 5-6-0; Away: 8-6-0)
• ATS Record When Favored by 4.5+: 0-2-0 (As Favorite: 0-2-0; As Underdog: 13-10-0)
• O-U-P: 11-14-0 (Home: 5-6-0; Away: 6-8-0)
• Record When Moneyline Favorite: 1-1 (Home: 1-0; Away: 0-1)
• Record When Moneyline Underdog: 7-14 (Home: 5-5; Away: 2-9)

Need to know more about sports betting before you put down a wager on Eastern Illinois vs. Southern Indiana? Here’s everything you need to know about how to bet.

Southern Indiana statistics, trends and more

As the away team

• Southern Indiana has been better against the spread on the road (6-6-0) than at home (2-9-0) this season.
• Screaming Eagles games have gone above the over/under 27.3% of the time at home (three of 11), and 33.3% of the time away (four of 12).
• The Screaming Eagles, as moneyline underdogs, have won a lower percentage of games at home (0-7) than on the road (2-9) this year.

Recent trends

• The Screaming Eagles have performed worse offensively over their previous 10 games, averaging 66.1 points per contest, 2.7 fewer points their than season average of 68.8.
• Southern Indiana has fared better defensively in its previous 10 games, giving up 71.8 points per contest, 1.9 fewer points than its season average of 73.7 allowed.
• The Screaming Eagles are sinking 6.6 three-pointers per game in their past 10 games, which is 1.1 fewer three-pointers than their average for the season (7.7). Additionally, they own a worse three-point percentage over their previous 10 contests (29.5%) compared to their season average from downtown (30.8%).

Southern Indiana betting records this season

• ATS Record: 10-15-0 (Home: 2-9-0; Away: 6-6-0)
• ATS Record When Underdog by 4.5+: 8-9-0 (As Favorite: 2-3-0; As Underdog: 8-12-0)
• O-U-P: 9-16-0 (Home: 3-8-0; Away: 4-8-0)
• Record When Moneyline Favorite: 2-3 (Home: 1-3; Away: 1-0)
• Record When Moneyline Underdog: 2-18 (Home: 0-7; Away: 2-9)