Michigan vs. Saint Louis betting: March Madness Second Round preview for March 21

Data Skrive

The No. 9 seed Saint Louis Billikens (29-5) are 12.5-point underdogs in their second round NCAA Tournament matchup against the No. 1 seed Michigan Wolverines (32-3) on Saturday at 12:10 p.m. ET on CBS. The winner advances to the Sweet 16 in the Midwest Region bracket. The matchup’s over/under is 161.5.

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Spread

Michigan Cover -12.5 vs Saint Louis -110

Bet $20, Payout $38.18

Michigan vs. Saint Louis betting lines

  • Michigan moneyline odds to win: -952
  • Saint Louis moneyline odds to win: +602
  • Spread: Michigan (-12.5)
  • Total: 161.5

Michigan statistics, trends and more

Recent trends

  • In their last 10 games, the Wolverines have been scoring 78.8 points per game, an average that’s significantly lower than the 87.2 they’ve scored over the course of the 2025-26 season.
  • Michigan has been more porous on defense lately, allowing 72.5 points per game over its past 10 contests compared to the 69.5 points per game its opponents are averaging over the 2025-26 season.
  • Over their past 10 outings, the Wolverines are making 0.3 fewer three-pointers per game than their season long average (8.8 compared to 9.1 season-long), while shooting a higher percentage from beyond the arc in that span (38.8% compared to 36.3% season-long).

Michigan betting records this season

  • ATS Record: 16-19-0 (Home: 9-6-0; Away: 4-7-0)
  • ATS Record When Favored by 12.5+: 8-14-0 (As Favorite: 15-19-0; As Underdog: 1-0-0)
  • O-U-P: 14-21-0 (Home: 6-9-0; Away: 4-7-0)
  • Record When Moneyline Favorite: 31-3 (Home: 14-1; Away: 11-0)
  • Record When Moneyline Underdog: 1-0 (Home: 0-0; Away: 0-0)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
51.0 (sixth in nation) 38.5 (second) 36.6 (19th) 26.9 (12th) 18.7 (fourth) 11.6 (248th)

Need to know more about sports betting before you put down a wager on Michigan vs. Saint Louis? Here’s everything you need to know about how to bet.

Saint Louis statistics, trends and more

Recent trends

  • In their previous 10 games, the Billikens are putting up 79.8 points per contest, compared to their season average of 87.7.
  • Saint Louis is allowing 74.7 points per contest in its last 10 games, which is 5.0 more points than it is allowing for the season (69.7).
  • The Billikens are sinking 1.4 fewer threes per contest in their previous 10 games (9.5) compared to their season average (10.9), and they are producing a lower three-point percentage over their last 10 contests (37.4%) compared to their season mark (39.8%).

Saint Louis betting records this season

  • ATS Record: 19-14-0 (Home: 13-5-0; Away: 5-5-0)
  • O-U-P: 17-16-0 (Home: 10-8-0; Away: 5-5-0)
  • Record When Moneyline Favorite: 26-5 (Home: 18-0; Away: 6-3)
  • Record When Moneyline Underdog: 2-0 (Home: 0-0; Away: 1-0)
Field Goal % Opp. Field Goal % Rebounds Opp. Rebounds Assists Turnovers
51.2 (fifth in nation) 37.7 (first) 36.9 (14th) 29.4 (79th) 18.6 (sixth) 12.3 (305th)
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About Ryan Knuppel

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