The Syracuse Orange (3-7) visit the No. 9 Notre Dame Fighting Irish (8-2) at Notre Dame Stadium on Saturday, November 22, 2025.

The Orange are expected to lose by at least two TDs (currently +36.5) against the Fighting Irish (with an over/under of 50.5 points).

Below you can find our betting primer for this this game between the Fighting Irish and the Orange, and uncover all of our predictions here, too!

Notre Dame vs. Syracuse betting lines

• Spread favorite: Fighting Irish (-36.5)
• Moneyline: Fighting Irish (), Orange ()
• Total: 50.5 points
• TV Channel: NBC (WBGH-Binghamton, NY)
• Live Stream: Fubo

Notre Dame vs. Syracuse betting info and stats

Notre Dame has an against-the-spread record of 5-5-0 so far this season. Notre Dame is 8-2 in the 10 games this season it has been favored on the moneyline. Syracuse has a 4-5-1 record against the spread this season. Syracuse is an underdog on the moneyline for the eighth game this year and is 1-6 in that role.

Notre Dame vs. Syracuse recent stats and trends

Notre Dame Fighting Irish

• Notre Dame is 2-1 against the spread over its past three games, and has a 3-0 straight-up record in those matchups.
• One time in those three games, the final combined score surpassed the set total.
• Notre Dame’s past three outings have ended with an average of 55.2 points scored. That’s 4.7 more points than this contest’s over/under.

Syracuse Orange

• Syracuse is 1-2 against the spread and 3-0 overall during its last three games.
• The final combined score of the last three Syracuse games has gone over the set total twice.
• Syracuse’s past three outings have ended with an average of 48.2 points scored. That’s 2.3 fewer points than this contest’s over/under.

Notre Dame vs. Syracuse key players

Notre Dame Fighting Irish

• CJ Carr has 2,487 passing yards for Notre Dame, completing 67.3% of his passes and throwing 21 touchdowns and six interceptions this season.
• Jeremiyah Love has racked up 1,135 yards on 177 carries while finding the end zone 14 times as a runner. He’s also caught 26 passes for 274 yards (30.4 per game) and three touchdowns through the air.
• Jadarian Price has been handed the ball 103 times this year and racked up 589 yards (58.9 per game) with nine touchdowns.
• Malachi Fields’ 596 yards as a receiver pace the team. He’s been targeted 57 times and has registered 32 catches and five touchdowns.
• Jordan Faison has hauled in 44 receptions totaling 551 yards, finding the end zone three times as a receiver so far this campaign.
• Eli Raridon has been the target of 41 passes and compiled 30 catches for 473 yards, an average of 59.1 yards per contest.
• Boubacar Traore has 5.5 sacks to pace the team, and also has 6.0 TFL and 30 tackles.
• Notre Dame’s top-tackler, Drayk Bowen, has 46 tackles, 1.0 TFL, and two sacks this year.
• Tae Johnson leads the team with four interceptions, while also collecting 37 tackles and four passes defended.

Syracuse Orange

• Steve Angeli has recored 1,352 passing yards, or 338.0 per game, so far this season. He has completed 62.8% of his passes and has recorded 10 touchdowns with two interceptions.
• Yasin Willis has rushed for 558 yards on 130 carries so far this year while scoring four times on the ground.
• Will Nixon has totaled 326 yards on 77 carries with three touchdowns, while also catching 20 passes for 157 yards.
• Johntay Cook II has registered 41 receptions this season and his team-high yardage total sits at 518 (51.8 yards per game). He’s been targeted 67 times and has two touchdowns.
• Darrell Gill Jr. has caught 29 passes and compiled 477 receiving yards (47.7 per game) with five touchdowns.
• Dan Villari’s 33 receptions (on 46 targets) have netted him 379 yards (37.9 ypg).
• Kevin Jobity Jr. has collected 5.0 sacks to pace the team, while also picking up 6.0 TFL and 21 tackles.
• Antoine Deslauriers is the team’s top-tackler this year. He’s picked up 50 tackles, 2.0 TFL, and one sack.
• Davien Kerr leads the team with three interceptions, while also recording 12 tackles and three passes defended.