SEC opponents meet when the No. 12 Vanderbilt Commodores (8-2) and the Kentucky Wildcats (5-5) square off on Saturday, November 22, 2025 at FirstBank Stadium.

The Commodores are significant favorites (-8.5) in their game against the Wildcats, with the over/under being 54.5 points. (In terms of the moneyline, the Commodores are -338 and the Wildcats are +268.)

Keep reading to check out our preview for this this game between the Commodores and the Wildcats, and uncover all of our predictions here, too!

Vanderbilt vs. Kentucky betting lines

• Spread favorite: Commodores (-8.5)
• Moneyline: Commodores (-338), Wildcats (+268)
• Total: 54.5 points
• TV Channel: ESPN
• Live Stream: Fubo

Vanderbilt vs. Kentucky betting info and stats

Vanderbilt has won eight games against the spread this season (8-2-0). Vanderbilt has covered the spread twice this season when listed as the favorite by at least 8.5 points. Vanderbilt has been favored on the moneyline in five games this season, and it has put together a 5-0 record in those outings. Kentucky has five wins against the spread in 10 opportunities this season (5-5-0). In the four games Kentucky has been the underdog by at least 8.5 points, it covered the spread three times (3-1). Kentucky’s record is 2-5 when playing as the underdog this year.

Vanderbilt vs. Kentucky recent stats and trends

Vanderbilt Commodores

• Vanderbilt is a perfect 3-0 against the spread over its last three games, and has a 2-1 straight-up record in those contests.
• The final combined score of the past three Vanderbilt games has exceeded the set total two times.
• The last three Vanderbilt games averaged 48.7 total points, 5.8 fewer points than this matchup’s point total.

Kentucky Wildcats

• Kentucky has covered the spread in each of its last three matchups while putting up a 2-1 record straight-up in those games.
• Two times in those three games, the final combined score has exceeded the set total.
• The last three Kentucky games averaged 47.0 total points, 7.5 fewer points than this matchup’s over/under.

Vanderbilt vs. Kentucky key players

Vanderbilt Commodores

• Diego Pavia has thrown for 2,440 yards, completing 70% of his passes and collecting 21 touchdowns and five interceptions this season. He’s also run for 613 yards (61.3 ypg) on 117 carries with seven rushing touchdowns.
• This season, Sedrick Alexander has carried the ball 89 times for 441 yards (44.1 per game) and eight touchdowns.
• Eli Stowers’ leads his squad with 665 yards as a receiver. He’s racked up that yardage on 50 receptions (out of 72 targets) and scored four touchdowns.
• Junior Sherrill has caught 35 passes for 470 yards (47.0 yards per game) and six touchdowns this year.
• Tre Richardson has been the target of 48 passes and compiled 29 receptions for 449 yards, an average of 49.9 yards per contest. He’s found the end zone two times through the air this season.
• Miles Capers has collected 4.5 sacks to lead the team, while also recording 6.0 TFL and 26 tackles.
• Bryan Longwell is the team’s tackle leader this year. He’s amassed 54 tackles, 4.0 TFL, and one interception.
• Zaylin Wood has a team-leading one interception to go along with 23 tackles, 3.0 TFL, three sacks, and one pass defended.

Kentucky Wildcats

• Cutter Boley has compiled 1,780 yards on 68.8% passing while tossing 13 touchdown passes with eight interceptions this season. He’s also run for 120 yards with two scores.
• Seth McGowan has rushed for 693 yards on 153 carries so far this year while scoring 12 times on the ground.
• Dante Dowdell has racked up 102 carries and totaled 528 yards with three touchdowns.
• Kendrick Law has racked up 519 receiving yards on 47 receptions to pace his team so far this season while scoring three touchdowns as a receiver.
• Hardley Gilmore IV has put together a 232-yard season so far with one touchdown. He’s caught 21 passes on 39 targets.
• Willie Rodriguez’s 31 targets have resulted in 16 grabs for 217 yards and one touchdown.
• Steven Soles Jr. has 3.5 sacks to lead the team, and also has 1.0 TFL and 10 tackles.
• Ty Bryant has 54 tackles, 1.0 TFL, and three interceptions, and leads the team in both tackles and interceptions.