The Penn State Nittany Lions (3-2) host a Big Ten showdown against the Northwestern Wildcats (3-2) on Saturday, October 11, 2025 at West Shore Home Field at Beaver Stadium.

The Nittany Lions are very big favorites (currently -21.5) in their game against the Wildcats, with the over/under being 47.5 points. (In terms of the moneyline, the Nittany Lions are -1695 and the Wildcats are +936.)

Keep reading to check out our betting primer for this this matchup between the Nittany Lions and the Wildcats, and uncover all of our betting picks here, too!

Penn State vs. Northwestern betting lines

• Spread favorite: Nittany Lions (-21.5)
• Moneyline: Nittany Lions (-1695), Wildcats (+936)
• Total: 47.5 points
• TV Channel: FOX Sports 1
• Live Stream: Fubo

Penn State vs. Northwestern betting info and stats

Penn State, through five games with a spread so far this season, is 0-5-0 against the spread. Penn State has yet to cover the spread when favorites by at least 21.5 points (a 0-4 ATS record). Penn State has won one of its three games played as the moneyline favorite this season. Northwestern has three wins against the spread in five opportunities so far this season (3-2-0). In the one game Northwestern has been an underdog by at least 21.5 points this season, it has covered the spread. This is the third time this year Northwestern is an underdog on the moneyline, after losing the previous two such games.

Penn State vs. Northwestern recent stats and trends

Penn State Nittany Lions

• Penn State is winless against the spread (0-3) and 1-2 overall in its last three matchups.
• Penn State and its opponents have combined to hit the over all three times in those games.
• Penn State’s past three outings have ended with an average of 52.5 points scored. That’s 5.0 more points than this contest’s over/under.

Northwestern Wildcats

• Northwestern is 2-1 against the spread over its past three games and has a 1-2 straight-up record in those contests.
• Northwestern and its opponents have hit the over once in those games.
• The past three Northwestern games averaged 1.7 fewer points (45.8) than this matchup’s point total.

Penn State vs. Northwestern key players

Penn State Nittany Lions

• Drew Allar has compiled 963 yards (192.6 ypg) on 90-of-139 passing with eight touchdowns compared to two interceptions this season. In addition, he’s added 147 rushing yards (29.4 ypg) on 30 carries.
• Kaytron Allen has 377 rushing yards on 54 carries with six touchdowns.
• Nicholas Singleton has racked up 239 yards on 63 carries, scoring five times. He’s caught 10 passes for 89 yards (17.8 per game), as well.
• Kyron Ware-Hudson’s leads his squad with 208 yards as a receiver. He’s racked up that yardage on 18 catches (out of 32 targets) and scored two touchdowns.
• Luke Reynolds has reeled in 18 passes while averaging 39.4 yards per game.
• Trebor Pena has hauled in 18 receptions for 197 yards, an average of 39.4 yards per game. He’s scored one time as a receiver this season.
• Dani Dennis-Sutton has racked up 2.0 sacks to pace the team, while also picking up 4.0 TFL and 19 tackles.
• Amare Campbell, Penn State’s leading tackler, has 46 tackles, 5.0 TFL, and two sacks this year.
• Jahmir Joseph has a team-leading one interception to go along with one pass defended.

Northwestern Wildcats

• Preston Stone has 918 passing yards, or 183.6 per game, so far this season. He has completed 61.5% of his passes and has thrown seven touchdowns with six interceptions.
• The team’s top rusher, Caleb Komolafe, has carried the ball 76 times for 344 yards (68.8 per game) with four touchdowns.
• Joseph Himon II has collected 208 yards (on 38 carries).
• Griffin Wilde leads his squad with 375 receiving yards on 25 catches with two touchdowns.
• Hunter Welcing has 10 receptions (on 10 targets) for a total of 109 yards (21.8 yards per game) and one touchdown this year.
• Hayden Eligon II has racked up 108 reciving yards (27.0 ypg) and two touchdowns this season.
• Aidan Hubbard paces the team with 2.5 sacks, and also has 3.0 TFL and 13 tackles.
• Robert Fitzgerald is the team’s tackle leader this year. He’s racked up 41 tackles and 2.0 TFL.
• Mac Uihlein leads the team with two interceptions, while also putting up 34 tackles, 2.0 TFL, and two passes defended.