ACC foes meet when the Pittsburgh Panthers (6-2) and the Stanford Cardinal (3-5) square off on Saturday, November 1, 2025 at Stanford Stadium.

The Panthers are very heavy favorites (currently -14) in their matchup versus the Cardinal, with the over/under at 51.5 points. (In terms of the moneyline, the Panthers are -606 and the Cardinal are +433.)

Keep reading to check out our betting primer for this this contest between the Panthers and the Cardinal, and find all of our expert picks here, too!

Pittsburgh vs. Stanford betting lines

• Spread favorite: Panthers (-14)
• Moneyline: Panthers (-606), Cardinal (+433)
• Total: 51.5 points
• TV Channel: ACC Network
• Live Stream: Fubo

Pittsburgh vs. Stanford betting info and stats

Pittsburgh has an against-the-spread record of 6-2-0 so far this season. In two games played when favored by at least 14 points, Pittsburgh is undefeated ATS at 2-0. Pittsburgh has won five of its six games played when favored on the moneyline this season. Stanford has two wins against the spread so far this season (2-6-0). When Stanford is an underdog of 14 or more points, it has gone 2-4 ATS. Stanford has a 2-5 record this year in games it hs played as moneyline underdogs.

Pittsburgh vs. Stanford recent stats and trends

Pittsburgh Panthers

• Pittsburgh has covered the spread in its last three matchups while putting up a 3-0 record straight-up in those games.
• In two of those three games, the final combined score has surpassed the set total.
• The last three Pittsburgh games averaged 55.2 total points, 3.7 more points than this matchup’s point total.

Stanford Cardinal

• Stanford is 1-2 against the spread and 3-0 overall during its last three contests.
• One time in those three games, the final combined score went over the set total.
• The last three Stanford games averaged 51.8 total points, 0.3 more points than this matchup’s point total.

Pittsburgh vs. Stanford key players

Pittsburgh Panthers

• Mason Heintschel has racked up 1,246 yards (249.2 ypg) on 95-of-146 passing with nine touchdowns compared to three interceptions this season. In addition, he’s added 122 rushing yards (30.5 ypg) on 41 carries while scoring one touchdown on the ground.
• The team’s top rusher, Ja’Kyrian Turner, has carried the ball 66 times for 274 yards (39.1 per game), scoring six times.
• Desmond Reid has been handed the ball 55 times this year and racked up 266 yards (44.3 per game) with two touchdowns. He’s also helped out in the passing game with 17 grabs for 254 yards and two touchdowns.
• Raphael Williams’ team-leading 528 yards as a receiver have come on 33 catches (out of 53 targets) with five touchdowns.
• Kenny Johnson has hauled in 32 receptions totaling 465 yards, finding the end zone three times as a receiver so far this campaign.
• Cataurus Hicks has racked up 17 grabs for 336 yards, an average of 42.0 yards per game. He’s scored four times as a receiver this season.
• Blaine Spires has racked up 2.5 sacks to pace the team, while also recording 4.0 TFL and 12 tackles.
• Rasheem Biles has been all over the field, leading the team in both tackles and interceptions. He has 51 tackles, 5.0 TFL, two sacks, and one interception so far.

Stanford Cardinal

• Ben Gulbranson has 1,585 passing yards, or 198.1 per game, so far this season. He has completed 57% of his passes and has recorded eight touchdowns with seven interceptions.
• The team’s top rusher, Micah Ford, has carried the ball 99 times for 425 yards (60.7 per game) with three touchdowns. He’s also caught eight passes for 77 yards.
• Cole Tabb has taken 86 carries and totaled 365 yards with two touchdowns.
• CJ Williams has collected 40 receptions this season and his team-high yardage total sits at 476 (59.5 yards per game). He’s been targeted 68 times and has two touchdowns.
• Bryce Farrell has put up a 400-yard season so far with one touchdown. He’s caught 22 passes on 32 targets.
• Sam Roush’s 29 grabs (on 52 targets) have netted him 305 yards (38.1 ypg) and two touchdowns.
• Clay Patterson has racked up 3.0 sacks to pace the team, while also picking up 2.0 TFL and 15 tackles.
• Matt Rose, Stanford’s top tackler, has 58 tackles, 4.0 TFL, and one sack this year.
• Collin Wright has a team-high one interception to go along with 20 tackles, 1.0 TFL, and one pass defended.